TB4-FRAG

What is Thymosin Beta 4 Peptide?

Thymosin Beta 4 (TB4) is a naturally occurring multi-domain (multiple active sections) peptide that is produced in the thymus gland. The thymus starts shrinking around age 15 and continues to decline until approximately 80-90% of its activity has decreased by age 40, this is when the chronic diseases of aging start becoming more prevalent. The CDC states that approximately 80% of aged individuals are affected by at least one chronic disease due to declination of thymus related immune function [20,21].  TB4 provides a range of beneficial effects with the ability to stimulate and support tissue repair, healing, and regeneration for a range of tissues and organ systems [2,4].  TB4 is shown to support the down-regulation of inflammation and pain; [2,15] increase ATP (energy) production and protect and repair mitochondria; [1,2] increase antioxidant and glutathione production; [2,3,4,7,15] improve IGF-1 levels; [2] stimulate stem cell proliferation, activity, function and maturation. [4,5,13] Additionally, TB4 has significant antimicrobial functions; [1,2,4], helps maintain a normal and balanced immune system; [16,19] provides support and defense against environmental and internal toxins, including, pesticides, pollutants, antibiotics, alcohol, endotoxins mycotoxins and neurotoxins from infections and external sources; [1,15,18] modulates dysfunctional immunity; [1-5,8,9,14,16,19,20,21] supports the body’s repair functions in multiple systems of the body.;[ 2,10,15] and supports the body’s ability to stay healthy during aging [2,8,10,12,15,16,19].

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Because full-length TB4 is 43 amino acids in length, it does not absorb orally, sub lingually or nasally. 

• TB4 Frag is only four amino acids in length and is fully orally absorbable.

• Studies show that this four amino acid fragment maintains the immune-modulatory, healing as well as anti-inflammatory benefits of the complete TB4. 

• TB4 fragment eliminates some of the few potential side-effects of full-lengthTB4, including eliminating the domain (AA 17-23) that stimulates mast cells. The active fragment is approximately ten times as potent as the full TB4 peptide on a per weight basis. 

TB4 Fragment 1-4 is the workhorse of full-length TB4, possessing the immune-modulatory, angiogenic, healing, anti-inflammatory, cellular protective and repair actions of full-length TB4. TB4 Frag differentiates itself from full-length TB4 in the following ways: 

• Orally active (absorbs intact). 

• More potent antifibrotic.

• Ten times the potency of full-length TB4 by weight.

• Does not stimulate mast cell activation (segment 17-23). 

• Crosses Blood Brain Barrier while full-length TB4 does not. 

• Inhibits HTBFb induced Plasminogen Activator Inhibitor-1 (PAI-1), helping prevent the hypercoagulability seen with chronic illness [1,13].